Vitoss BA2X Bioactive Bone Graft Substitute

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  • Vitoss BA2X Bioactive Bone Graft Substitute

Vitoss BA2X Bioactive Bone Graft Substitute
Category: Biomaterials

A synthetic bone graft that has increased levels of bioactive glass compared to Vitoss BA, and has a unique porosity, structure, and chemistry to help drive 3D regeneration of bone

Description

Vitoss BA2X contains increased levels of bioactive glass. In-vitro testing showed that it induced two times the deposition of calcium phosphate onto the surface of an implant while retaining the same handling properties.1
 
  • Highly porous calcium-phosphate (up to 90% porous)2 containing bioactive glass 
  • Stable at physiological pH3 and resorbs during the natural remodeling process of bone4
  • The addition of bioactive glass helps create a surface favorable for osteoblast attachment5-11
  • Vitoss BA2X Foam Pack is stable in a fluid environment, can soak and hold bone marrow, and is moldable
 
Note: In-vitro bioactivity testing has not been evaluated in human clinical trials.
 
References:
  1. Stryker Spine Test Report P/N 1000-2024R
  2. Stryker Spine Test Report P/N 1070-0008R
  3. Rey C, Combes C, Drouet C, Grossin D. (2011). Bioactive Ceramics - Physical Chemistry. In Ducheyne, Paul. Comprehensive Biomaterials. 1. Elsevier. pp. 187–281. 
  4. Anker et al, Ultraporous Beta-Tricalcium Phosphate is Well Incorporated in Small Cavitary Defects. Clinical Orthopaedics and Related Research, 2005 May; 434: 251-7.
  5. Hench, L.L., Splinter, R.J., and Allen, W.C., Bonding Mechanisms at the Interface of Ceramic Prosthetic Materials. Journal of Biomedical Materials Research, 1971; 2(1): 117-141.
  6. Hench, L.L., Paschall, H.A., Direct Chemical Bond of Bioactive Glass-Ceramic Materials to Bone and Muscle. Journal of Biomedical Materials Research, 1973; 4: 25-42.
  7. Gross, U., The Interface of Various Glasses and Glass Ceramics with a Bony Implantation Bed. Journal of Biomedical Materials Research, 1985; 19: 251-271.
  8. Vrouwenvelder, W.C.A., Histological and Biochemical Evaluation of Osteoblasts Cultured on Bioactive Glass, Hydroxylapatite, Titanium Alloy, and Stainless Steel. Journal of Biomedical Materials Research, 1993 Apr; 27(4): 465-75.
  9. Sanders, D.M., Hench, L.L., Mechanisms of Glass Corrosion. Journal of American Ceramic Society.1973; 56(7): 373-377.
  10. Hench, L.L., Characterization of Glass Corrosion and Durability. Journal of Non-Crystalline Solids, 1975; 19: 27-39.
  11. Ogino, M., Hench, L.L., Formation of Calcium Phosphate Films on Silicate Glasses. Journal of Non-Crystalline Solids, 1980; 38 and 39: 673-678.
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